Rapgef3^tm1.1Flh
Targeted Allele Detail

Summary

• Symbol: Rapgef3^tm1.1Flh
• Name: Rap guanine nucleotide exchange factor (GEF) 3; targeted mutation 1.1, Frank Lezoualc'h
• MGI ID: MGI:5763386
• Synonyms: Epac1^flox
• Gene: Rapgef3 Location: Chr15:97642651-97665853 bp, - strand Genetic Position: Chr15, 53.74 cM
• Alliance: Rapgef3^tm1.1Flh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230297
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 8. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 15. Flp-mediated recombination removed the selection cassette and left exons 8 through 15 floxed. (J:230297)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rapgef3 Mutation: 49 strains or lines available

References

• Original: J:230297 Laurent AC, et al., Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Cardiovasc Res. 2015 Jan 1;105(1):55-64
• All: 2 reference(s)