Hras^tm1Khai
Targeted Allele Detail

Summary

• Symbol: Hras^tm1Khai
• Name: Hras proto-oncogene, GTPase; targeted mutation 1, Kevin Haigis
• MGI ID: MGI:5763197
• Synonyms: H-Ras^LSL, Lox-Stop-Lox (LSL)-H-Ras^G12V
• Gene: Hras Location: Chr7:140770839-140773938 bp, - strand Genetic Position: Chr7, 86.48 cM
• Alliance: Hras^tm1Khai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224229
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A floxed puromycin resistance cassette and 4 copies of the polyadenylation sequence was inserted upstream of a modified exon 1. The sequence of exon 1 was modified to create the amino acid substitution of valine for glycine at position 12 (G12V). (J:224229)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hras Mutation: 29 strains or lines available

References

• Original: J:224229 Bender RH, et al., Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner. Stem Cells. 2015 Jun;33(6):1998-2010
• All: 1 reference(s)