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Gabra1tm1.1Krmr
Targeted Allele Detail
Nomenclature
Symbol: Gabra1tm1.1Krmr
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1; targeted mutation 1.1, Richard Kramer
MGI ID: MGI:5763100
Synonyms: alpha1-GABAsubA/subPhoRM, alpha1T125C, PhoRM
Gene: Gabra1  Location: Chr11:42021766-42073757 bp, - strand  Genetic Position: Chr11, 24.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:230569
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Single point mutation
 
Mutation detailsThe allele was designed to introduce a threonine-to-cysteine mutation at codon 152 (T152C counting from the start codon; or T125C in the mature peptide sequence) into exon 5 of the gene. The targeting vector also includes a loxP-flanked neomycin selection cassette upstream of exon 5, as well as a C-to-T silent mutation in the exon 5 DNA sequence (to create a HindIII site upstream of T152C for genotyping). Cre-mediated recombination removed the floxed neo cassette. (J:230569)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabra1 Mutation:  24 strains or lines available
References
Original:  J:230569 Lin WC, et al., A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA(A) Receptors and Synaptic Inhibition. Neuron. 2015 Dec 2;88(5):879-91
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory