Kit^tm1.1Takk
Targeted Allele Detail

Summary

• Symbol: Kit^tm1.1Takk
• Name: KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1.1, Takahiro Kunisada
• MGI ID: MGI:5762847
• Synonyms: Kit^2lox
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^tm1.1Takk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222747
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 10. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 10. Flp-mediated recombination removed the selection cassette and left exon 10 floxed. (J:222747)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 180 strains or lines available

References

• Original: J:222747 Aoki H, et al., Conditional Deletion of Kit in Melanocytes: White Spotting Phenotype Is Cell Autonomous. J Invest Dermatol. 2015 Jul;135(7):1829-38
• All: 1 reference(s)