Lrrk2^tm1.1Adre
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm1.1Adre
• Name: leucine-rich repeat kinase 2; targeted mutation 1.1, Alastair D Reith
• MGI ID: MGI:5759912
• Synonyms: LRRK2-G2019S^GSK
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm1.1Adre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230329
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting vector was designed to introduce a glycine to serine (G2019S) substitution at base pair 107/8 (GG to GC) in exon 41. An FRT-flanked neomycin cassette was introduced into exon 41. LoxP site are also included in the vector although the location is not specified. FLP recombinase mediated recombination removed the neo cassette. (J:230329)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 163 strains or lines available

References

• Original: J:230329 Steger M, et al., Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. Elife. 2016;5:e12813
• All: 4 reference(s)