Bcl2^tm1Tnr
Targeted Allele Detail

Summary

• Symbol: Bcl2^tm1Tnr
• Name: B cell leukemia/lymphoma 2; targeted mutation 1, Martin Turner
• MGI ID: MGI:5759800
• Synonyms: Bcl2-ARE^flox
• Gene: Bcl2 Location: Chr1:106465908-106642004 bp, - strand Genetic Position: Chr1, 49.76 cM
• Alliance: Bcl2^tm1Tnr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226968
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the AU-rich elements (ARE) in exon 2. An FRT-flanked neomycin resistance cassette, containing a flp recombinase gene, with a 3' loxP site was inserted downstream of the ARE in exon 2. Flp-mediated recombination removed the selection cassette. (J:226968)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2 Mutation: 42 strains or lines available

Notes

ES cell line = Bruce6

References

• Original: J:226968 Diaz-Munoz MD, et al., Deletion of AU-rich elements within the Bcl2 3'UTR reduces protein expression and B cell survival in vivo. PLoS One. 2015;10(2):e0116899
• All: 1 reference(s)