Oprm1^tm4Kff
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm4Kff
• Name: opioid receptor, mu 1; targeted mutation 4, Brigitte L Kieffer
• MGI ID: MGI:5755677
• Synonyms: MOR-mcherry, Oprm1^mch
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm4Kff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230181
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (No functional change, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a monomeric red fluorescent protein (mCherry), and an FRT-flanked neomycin resistance (neo) cassette, in exon 4, just upstream of the stop codon, of the opioid receptor, mu 1 (Oprm1) coding region. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:230181)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 55 strains or lines available

References

• Original: J:230181 Erbs E, et al., A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. Brain Struct Funct. 2015 Mar;220(2):677-702
• All: 11 reference(s)