Juptm1.1Chen
Targeted Allele Detail
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Symbol: |
Juptm1.1Chen |
Name: |
junction plakoglobin; targeted mutation 1.1, Ju Chen |
MGI ID: |
MGI:5755302 |
Synonyms: |
OriNax |
Gene: |
Jup Location: Chr11:100259784-100288589 bp, - strand Genetic Position: Chr11, 63.47 cM
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Alliance: |
Juptm1.1Chen page
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Wrinkled, looser skin, thinning of the epidermis, and lack of milk in the stomach of Juptm1.1Chen/Juptm1.1Chen pups
Show the 1 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Hypomorph) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 10. Exon 11 was replaced with a modified one in which a TG were deleted. This mutation mimics the mutation found in patients with Naxos disease and results in a premature stop codon in exon 12. Flp-mediated recombination removed the selection cassette. RT-PCR confirmed reduced transcript expression.
(J:222025)
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Generation of the Juptm1.1Chen allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Jup Mutation: |
162 strains or lines available
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Original: |
J:222025 Zhang Z, et al., Normalization of Naxos plakoglobin levels restores cardiac function in mice. J Clin Invest. 2015 Apr;125(4):1708-12 |
All: |
1 reference(s) |
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