Mir1a-1hg^tm1Thbr
Targeted Allele Detail

Summary

• Symbol: Mir1a-1hg^tm1Thbr
• Name: Mir1a-1 and Mir133a-2 host gene; targeted mutation 1, Thomas Braun
• MGI ID: MGI:5755257
• Synonyms: miR-1-1/133a-2^-
• Gene: Mir1a-1hg Location: Chr2:180027397-180042907 bp, + strand Genetic Position: Chr2, 102.92 cM
• Alliance: Mir1a-1hg^tm1Thbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202466
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mir1a-1hg^tm1Thbr involves 2 genes/genome features (Mir1a-1, Mir133a-2) View all
• Mutation details: A floxed cassette containing an IRES sequence, lacZ reporter gene and neomycin resistance cassette replaced the sequence between (and including) Mir1a-1 to Mir133a-2. (J:202466)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir1a-1hg Mutation: 0 strains or lines available

References

• Original: J:202466 Wystub K, et al., miR-1/133a clusters cooperatively specify the cardiomyogenic lineage by adjustment of myocardin levels during embryonic heart development. PLoS Genet. 2013 Sep;9(9):e1003793
• All: 4 reference(s)