Creb1^tm1.1Nes
Targeted Allele Detail

Summary

• Symbol: Creb1^tm1.1Nes
• Name: cAMP responsive element binding protein 1; targeted mutation 1.1, Eric Nestler
• MGI ID: MGI:5755164
• Synonyms: Creb^floxed, Creb^loxP
• Gene: Creb1 Location: Chr1:64571963-64643707 bp, + strand Genetic Position: Chr1, 32.74 cM, cytoband C1/C5
• Alliance: Creb1^tm1.1Nes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229961
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:229961)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Creb1 Mutation: 59 strains or lines available

Notes

ES Cell Line = 81E10-40F (Cell & Molecular Technologies)

Strain of Origin: C57BL/6J

References

• Original: J:229961 Covington HE 3rd, et al., A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron. 2011 Aug 25;71(4):656-70
• All: 9 reference(s)