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Targeted Allele Detail
Symbol: Ctnnal1tm1.1Sjm
Name: catenin (cadherin associated protein), alpha-like 1; targeted mutation 1.1, Sean Morrison
MGI ID: MGI:5755098
Synonyms: alpha-catulin-GFP
Gene: Ctnnal1  Location: Chr4:56810935-56865188 bp, - strand  Genetic Position: Chr4, 31.66 cM, cytoband C1
Germline Transmission:  Earliest citation of germline transmission: J:229960
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsMost of the exon 1 coding region and the exon 1 to intron 1 junction is replaced by an in-frame EGFP-bGH-pA-FRT-neo-FRT cassette via homologous recombination. Flp-mediated recombination removed the FRT-flanked neo cassette. Although predicted to be a loss-of-function allele, both heterozygous and homozygous mice exhibit no obvious phenotypic abnormalities. (J:229960)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ctnnal1 Mutation:  167 strains or lines available
Original:  J:229960 Acar M, et al., Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal. Nature. 2015 Oct 1;526(7571):126-30
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory