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Tox3em1(IMPC)Tcp
Endonuclease-mediated Allele Detail
Summary
Symbol: Tox3em1(IMPC)Tcp
Name: TOX high mobility group box family member 3; endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI ID: MGI:5755092
Gene: Tox3  Location: Chr8:90973668-91074971 bp, - strand  Genetic Position: Chr8, 43.96 cM
Alliance: Tox3em1(IMPC)Tcp page
IMPC: Tox3 gene page
Mutation
origin
Strain of Origin:  C57BL/6NCrl
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThis allele produced from project TCPR0331 at TCP by injecting Cas9 mRNA and one guide RNA with the spacer sequence GGGAAGGCAACGGATCGCTG. This resulted in a 4 bp deletion from Chr8:90270347 to 90270350 in ENSMUSE00000331868. This mutation is predicted to cause a frameshift with amino acid changes after residue 96 and early truncation 53 amino acids later (p.S96Rfs*55). (GRCm38). (J:165963)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tox3 Mutation:  38 strains or lines available
References
Original:  J:165963 Centre for Modeling Human Disease, Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto. MGI Direct Data Submission. 2010;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory