Scn1a^em6(IMPC)Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scn1a^em6(IMPC)Tcp
• Name: sodium channel, voltage-gated, type I, alpha; endonuclease-mediated mutation 6, The Centre for Phenogenomics
• MGI ID: MGI:5755084
• Gene: Scn1a Location: Chr2:66101125-66271181 bp, - strand Genetic Position: Chr2, 39.13 cM
• Alliance: Scn1a^em6(IMPC)Tcp page
• IMPC: Scn1a gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele, from project TCPR0246, was generated at The Centre for Phenogenomics by injecting Cas9 mRNA and one guide RNA with spacer sequence AGTCGTTCATGTGCCAACGT. This resulted in a 1 bp insertion at Chr2:66319540 in OTTMUSE00000158516. This mutation is predicted to cause a frameshift with amino acid changes after residue 932 and early truncation 63 amino acids later (p.W932Lfs*65). (GRCm38). (J:165963)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scn1a Mutation: 114 strains or lines available

References

• Original: J:165963 Centre for Modeling Human Disease, Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto. MGI Direct Data Submission. 2010
• All: 2 reference(s)