Pla2g6^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Pla2g6^{tm1c(EUCOMM)Hmgu}
• Name: phospholipase A2, group VI; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5754997
• Gene: Pla2g6 Location: Chr15:79170428-79212590 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Pla2g6^{tm1c(EUCOMM)Hmgu} page
• IMPC: Pla2g6 gene page

Mutation origin

• Mutant Cell Lines: HEPD0731_2_G05, HEPD0731_2_G07
• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The mutant allele has, from 5' to 3', an FRT site, an En2 splice acceptor cassette containing IRES, beta-galactosidase and polyA sequence, a loxP site, human beta-actin promoter, SV40 polyA, a second FRT site, and a second loxP site inserted upstream of exon 6. A third loxP-site is inserted downstream of exon 8. Flp-mediated recombination removed the FRT-flanked neo cassette and En2 splice acceptor leaving exons 6 through 8 floxed. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:157065)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pla2g6 Mutation: 67 strains or lines available

References

• Original: J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015
• All: 5 reference(s)