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Pla2g6tm1c(EUCOMM)Hmgu
Targeted Allele Detail
Nomenclature
Symbol: Pla2g6tm1c(EUCOMM)Hmgu
Name: phospholipase A2, group VI; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:5754997
Gene: Pla2g6  Location: Chr15:79286228-79328385 bp, - strand  Genetic Position: Chr15, 37.7 cM
Mutation
origin
Mutant Cell Lines:  HEPD0731_2_G05, HEPD0731_2_G07
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe mutant allele has, from 5' to 3', an FRT site, an En2 splice acceptor cassette containing IRES, beta-galactosidase and polyA sequence, a loxP site, human beta-actin promoter, SV40 polyA, a second FRT site, and a second loxP site inserted upstream of exon 6. A third loxP-site is inserted downstream of exon 8. Flp-mediated recombination removed the FRT-flanked neo cassette and En2 splice acceptor leaving exons 6 through 8 floxed. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:157065)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pla2g6 Mutation:  29 strains or lines available
References
Original:  J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory