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Grm6nob8
Spontaneous Allele Detail
Nomenclature
Symbol: Grm6nob8
Name: glutamate receptor, metabotropic 6; no b wave 8
MGI ID: MGI:5754533
Gene: Grm6  Location: Chr11:50850685-50866208 bp, + strand  Genetic Position: Chr11, 30.93 cM
Mutation
origin
Strain of Origin:  CBA/CaJ
Mutation
description
Allele Type:    Spontaneous (Hypomorph)
Mutation:    Single point mutation
 
Mutation detailsThis spontaneous A to T transversion at position Chr:11:50851337 (GRCm38) results in a missense mutation at position 66, changing methionine to leucine. This residue lies in the glutamate binding region and is invariant across many mammals including human. (J:240996)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grm6 Mutation:  31 strains or lines available
References
Original:  J:240996 Peachey NS, et al., A MISSENSE MUTATION IN GRM6 REDUCES BUT DOES NOT ELIMINATE MGLUR6 EXPRESSION OR ROD DEPOLARIZING BIPOLAR CELL FUNCTION. J Neurophysiol. 2017 May 10;:jn.00888.2016
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory