Nr2c1^tm1.2Jeng
Targeted Allele Detail

Summary

• Symbol: Nr2c1^tm1.2Jeng
• Name: nuclear receptor subfamily 2, group C, member 1; targeted mutation 1.2, James Douglas Engel
• MGI ID: MGI:5753072
• Gene: Nr2c1 Location: Chr10:93983885-94033073 bp, + strand Genetic Position: Chr10, 48.81 cM
• Alliance: Nr2c1^tm1.2Jeng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221922
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. A cDNA encoding the remaining exons, polyadenylation sequence, CFP reporter gene, FRT site, neomycin resistance gene, loxP site and FRT site were inserted downstream and in-frame of exon 5. Flp-mediated recombination removed the section cassette. Cre-mediated recombination removed exons 4 and 5 floxed leaving the reporter gene intact. (J:221922)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr2c1 Mutation: 77 strains or lines available

References

• Original: J:221922 Cui S, et al., Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic beta-type globin genes. Blood. 2015 Feb 26;125(9):1477-87
• All: 1 reference(s)