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Dnajc7tm1.2Neg
Targeted Allele Detail
Nomenclature
Symbol: Dnajc7tm1.2Neg
Name: DnaJ heat shock protein family (Hsp40) member C7; targeted mutation 1, Masahiko Negishi
MGI ID: MGI:5752955
Synonyms: CCRP deltaEx
Gene: Dnajc7  Location: Chr11:100582818-100620168 bp, - strand  Genetic Position: Chr11, 63.47 cM
Steatotic liver and increased cholesterol levels in Dnajc7tm1.2Neg/Dnajc7tm1.2Neg males

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:225381
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the exons 2-4. Western blot analysis confirmed the absence of protein expression in nucleus and cytoplasm extracts of liver tissue. (J:225381)
Generation of the Dnajc7tm1.1Neg and Dnajc7tm1.2Neg alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnajc7 Mutation:  87 strains or lines available
References
Original:  J:225381 Ohno M, et al., The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers. PLoS One. 2014;9(12):e115663
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory