Kcnq1ot1^tm1.2Neng
Targeted Allele Detail

Summary

• Symbol: Kcnq1ot1^tm1.2Neng
• Name: KCNQ1 overlapping transcript 1; targeted mutation 1.2, Nora Engel
• MGI ID: MGI:5752925
• Synonyms: Kcnq1ot1^PO
• Gene: Kcnq1ot1 Location: Chr7:142766848-142850284 bp, - strand Genetic Position: Chr7, 88.15 cM
• Alliance: Kcnq1ot1^tm1.2Neng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223238
• Parent Cell Line: ART B6-3, B6-3 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 564 bp minimal promoter was flanked with loxP sites. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. Cre-mediated recombination removed the minimal promoter (PO - promoter out). (J:223238)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnq1ot1 Mutation: 0 strains or lines available

References

• Original: J:223238 Schultz BM, et al., Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain. Nucleic Acids Res. 2015 Jan;43(2):745-59
• All: 1 reference(s)