Dnmt1^tm6.1Jrc
Targeted Allele Detail

Summary

• Symbol: Dnmt1^tm6.1Jrc
• Name: DNA methyltransferase 1; targeted mutation 6.1, Richard Chaillet
• MGI ID: MGI:5752873
• Synonyms: Dnmt1^KK-AA
• Gene: Dnmt1 Location: Chr9:20818501-20871084 bp, - strand Genetic Position: Chr9, 7.66 cM
• Alliance: Dnmt1^tm6.1Jrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223970
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 13 was replaced with a floxed neomycin resistance cassette and a modified exon 13 in which nucleotide substitutions replaced two lysines with alanine within the conserved region of the intrisically disordered domain (IDD). Cre-mediated recombination removed the selection cassette. (J:223970)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnmt1 Mutation: 108 strains or lines available

References

• Original: J:223970 Shaffer B, et al., The DNMT1 intrinsically disordered domain regulates genomic methylation during development. Genetics. 2015 Feb;199(2):533-41
• All: 1 reference(s)