Rfx6^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Rfx6^tm1.1Ics
• Name: regulatory factor X, 6; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5752638
• Synonyms: Rfx6^fl
• Gene: Rfx6 Location: Chr10:51553856-51606525 bp, + strand Genetic Position: Chr10, 25.74 cM
• Alliance: Rfx6^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222657
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:222657)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rfx6 Mutation: 50 strains or lines available

References

• Original: J:222657 Piccand J, et al., Rfx6 maintains the functional identity of adult pancreatic beta cells. Cell Rep. 2014 Dec 24;9(6):2219-32
• All: 2 reference(s)