Themis^m1Pgrs
Chemically induced Allele Detail

Summary

• Symbol: Themis^m1Pgrs
• Name: thymocyte selection associated; mutation 1, Philippe Gros
• MGI ID: MGI:5752602
• Synonyms: Themis^I23N
• Gene: Themis Location: Chr10:28544356-28759814 bp, + strand Genetic Position: Chr10, 16.06 cM
• Alliance: Themis^m1Pgrs page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion in exon 1 that results in the amino acid substitution of asparagine for isoleucine at position 23 (I23N). (J:223530)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Themis Mutation: 55 strains or lines available

References

• Original: J:223530 Torre S, et al., THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis. Infect Immun. 2015 Feb;83(2):759-68
• All: 1 reference(s)