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Ace2em#Yngh
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Ace2em#Yngh
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; endonuclease-mediated mutation, Huanming Yang
MGI ID: MGI:5752578
Synonyms: ACE2-KO
Gene: Ace2  Location: ChrX:162922338-162971414 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Mutation
origin
Strain of Origin:  Kunming
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTALEN technology was used to introduce mutations into exon 2. The population analyzed for phenotype contained individuals with alleles from 3 lines (#17, #20 and #24) containing: (1) a 4 bp deletion; (2) a 10 bp deletion; (3) a 3 bp deletion; (4) a 20 bp deletion with a single bp insertion; and (5) a single bp insertion. Northern blot analysis confirmed reduced expression of a long isoform. The short isoform is not detected in the colon of knock-out or control mice. The pound symbol (#) is used when no line is specified or lines are pooled. (J:221616)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:  23 strains or lines available
References
Original:  J:221616 Liu C, et al., Generation of outbred Ace2 knockout mice by RNA transfection of TALENs displaying colitis reminiscent pathophysiology and inflammation. Transgenic Res. 2015 Jun;24(3):433-46
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/14/2021
MGI 6.17
The Jackson Laboratory