Mef2d^tm1.2Meg
Targeted Allele Detail

Summary

• Symbol: Mef2d^tm1.2Meg
• Name: myocyte enhancer factor 2D; targeted mutation 1.2, Michael E Greenberg
• MGI ID: MGI:5752403
• Gene: Mef2d Location: Chr3:88049679-88079393 bp, + strand Genetic Position: Chr3, 38.78 cM
• Alliance: Mef2d^tm1.2Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221600
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 6 via homologous recombination. Cre mediated recombination removed the neo cassette and the 5 exons. (J:221600)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mef2d Mutation: 63 strains or lines available

References

• Original: J:221600 Andzelm MM, et al., MEF2D drives photoreceptor development through a genome-wide competition for tissue-specific enhancers. Neuron. 2015 Apr 8;86(1):247-63
• All: 1 reference(s)