Aoc3^tm1Geno
Targeted Allele Detail

Summary

• Symbol: Aoc3^tm1Geno
• Name: amine oxidase, copper containing 3; targeted mutation 1, Genoway
• MGI ID: MGI:5752179
• Synonyms: SSAO KO, Y471F
• Gene: Aoc3 Location: Chr11:101221432-101230256 bp, + strand Genetic Position: Chr11, 64.72 cM, cytoband B2-B5
• Alliance: Aoc3^tm1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220396
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion, Nucleotide substitutions
• Mutation details: A point mutation was introduced that changes an amino acid in the active site from Tyr to Phe. This disrupts semicarbazide-sensitive amine oxidase activity. Immunohistochemical analysis indicates that the expression pattern of the mutant protein is similar to wild-type. (J:220396)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aoc3 Mutation: 36 strains or lines available

References

• Original: J:220396 Weston CJ, et al., Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis. J Clin Invest. 2015 Feb;125(2):501-20
• All: 3 reference(s)