Mov10l1^tm2.1Jw
Targeted Allele Detail

Summary

• Symbol: Mov10l1^tm2.1Jw
• Name: Mov10 like RISC complex RNA helicase 1; targeted mutation 2.1, Jeremy Wang
• MGI ID: MGI:5751992
• Synonyms: Mov10l1^KI, Mov10l1^KI(K7778A)
• Gene: Mov10l1 Location: Chr15:88867112-88939355 bp, + strand Genetic Position: Chr15, 44.49 cM
• Alliance: Mov10l1^tm2.1Jw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221349
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Codon 778 in exon 17 was mutated from AAG (lysine to GCG (alanine) and a floxed neo cassette was inserted in intron 17 via homologous recombination. Cre mediated recombination removed the neo cassette. This mutations disrupts RNA helicase activity. (J:221349)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mov10l1 Mutation: 46 strains or lines available

References

• Original: J:221349 Vourekas A, et al., The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing. Genes Dev. 2015 Mar 15;29(6):617-29
• All: 1 reference(s)