Egln3^tm1.1Pec
Targeted Allele Detail

Summary

• Symbol: Egln3^tm1.1Pec
• Name: egl-9 family hypoxia-inducible factor 3; targeted mutation 1.1, Peter Carmeliet
• MGI ID: MGI:5751815
• Synonyms: Phd3^fl, PHD3^flox
• Gene: Egln3 Location: Chr12:54225767-54250646 bp, - strand Genetic Position: Chr12, 22.9 cM
• Alliance: Egln3^tm1.1Pec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225283
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:225283)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egln3 Mutation: 26 strains or lines available

References

• Original: J:225283 Henze AT, et al., Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nat Commun. 2014;5:5582
• All: 2 reference(s)