Schip1^tm1.1Lgo
Targeted Allele Detail

Summary

• Symbol: Schip1^tm1.1Lgo
• Name: schwannomin interacting protein 1; targeted mutation 1.1, Laurence Goutebroze
• MGI ID: MGI:5751809
• Synonyms: Schip1^delta10
• Gene: Schip1 Location: Chr3:67972135-68533814 bp, + strand Genetic Position: Chr3, 31.44 cM, cytoband E2
• Alliance: Schip1^tm1.1Lgo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221642
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 10 and a floxed EGFP/hygro cassette was inserted downstream of exon 11 via homologous recombination. Cre mediated recombination removed exon 10 and the EGFP/hygro cassette. Immunoblot analysis revealed the absence of both all wild-type isoforms and any truncated proteins in homozygous mutant mice. (J:221642)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Schip1 Mutation: 37 strains or lines available

References

• Original: J:221642 Klingler E, et al., The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development. Development. 2015 Jun 1;142(11):2026-36
• All: 2 reference(s)