Hprt1^{tm1(CAG-CASP6)Aclb}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(CAG-CASP6)Aclb}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Andrea C LeBlanc
• MGI ID: MGI:5751682
• Synonyms: Casp6 KI
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(CAG-CASP6)Aclb} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229300
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm1(CAG-CASP6)Aclb} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CASP6 (839)

  Casp6

  (MGI:1312921)

  Lacking the pro-domain, this protein is self-activating.

• Mutation details: The targeting construct introduced into the locus a CAG promoter, floxed stop cassette and the human sequence lacking its pro-domain (p20p10Casp6). Following cre-mediated recombination, a self-activating form of the protein of produced. (J:229300)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:229300 LeBlanc AC, et al., Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment. Cell Death Differ. 2014 May;21(5):696-706
• All: 3 reference(s)