P2ry6^tm1Bms
Targeted Allele Detail

Summary

• Symbol: P2ry6^tm1Bms
• Name: pyrimidinergic receptor P2Y, G-protein coupled, 6; targeted mutation 1, Bristol Myers Squibb
• MGI ID: MGI:5751477
• Gene: P2ry6 Location: Chr7:100586837-100623856 bp, - strand Genetic Position: Chr7, 54.46 cM
• Alliance: P2ry6^tm1Bms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223087
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• A lacZ and neomycin resistance cassette replaced the entire coding sequence contained within exon 3. (J:223087)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2ry6 Mutation: 17 strains or lines available

References

• Original: J:223087 Garcia RA, et al., P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development. PLoS One. 2014;9(10):e111385
• All: 1 reference(s)