Pdpn^tm1.1Snjt
Targeted Allele Detail

Summary

• Symbol: Pdpn^tm1.1Snjt
• Name: podoplanin; targeted mutation 1.1, Shannon J Turley
• MGI ID: MGI:5751460
• Synonyms: Deltacyto
• Gene: Pdpn Location: Chr4:142994001-143026134 bp, - strand Genetic Position: Chr4, 77.29 cM
• Alliance: Pdpn^tm1.1Snjt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222319
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct introduced three stop codons (TGA TAA TAG) into exon 5 immediately after the sequence encoding the transmembrane domain. Flp-mediated recombination removed the selection cassette that was inserted downstream of exon 6. (J:222319)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdpn Mutation: 31 strains or lines available

References

• Original: J:222319 Astarita JL, et al., The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture. Nat Immunol. 2015 Jan;16(1):75-84
• All: 1 reference(s)