Calcr^tm1.2Amli
Targeted Allele Detail

Summary

• Symbol: Calcr^tm1.2Amli
• Name: calcitonin receptor; targeted mutation 1.2, Michael Amling
• MGI ID: MGI:5751445
• Gene: Calcr Location: Chr6:3685680-3764714 bp, - strand Genetic Position: Chr6, 1.81 cM
• Alliance: Calcr^tm1.2Amli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222451
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 5. An additional loxP site was inserted downsteam of exon 7. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 6 and 7. (J:222451)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Calcr Mutation: 59 strains or lines available

References

• Original: J:222451 Keller J, et al., Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts. Nat Commun. 2014;5:5215
• All: 1 reference(s)