Dusp1^tm1.1Ambt
Targeted Allele Detail

Summary

• Symbol: Dusp1^tm1.1Ambt
• Name: dual specificity phosphatase 1; targeted mutation 1.1, Anton Bennett
• MGI ID: MGI:5751395
• Synonyms: Mkp-1^fl
• Gene: Dusp1 Location: Chr17:26724565-26727446 bp, - strand Genetic Position: Chr17, 13.28 cM, cytoband A2-C
• Alliance: Dusp1^tm1.1Ambt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224315
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:224315)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dusp1 Mutation: 26 strains or lines available

References

• Original: J:224315 Lawan A, et al., Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis. Mol Cell Biol. 2015 Jan;35(1):26-40
• All: 4 reference(s)