Vav2^tm1.1Xrb
Targeted Allele Detail

Summary

• Symbol: Vav2^tm1.1Xrb
• Name: vav guanine nucleotide exchange factor 2; targeted mutation 1.1, Xose R Bustelo
• MGI ID: MGI:5751213
• Synonyms: C-OncoVav2
• Gene: Vav2 Location: Chr2:27152116-27317045 bp, - strand Genetic Position: Chr2, 19.36 cM
• Alliance: Vav2^tm1.1Xrb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224320
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The targeting contruct introduced downstream of exon 1 a floxed STOP and neomycin resistance cassette, three hemagglutinin (HA) tags, a truncated Vav2 cDNA (delta1-184) and a human growth hormone polyadenylation sequence. This truncated version is phosphorylation-independent and has constitutitive exchange activity due to the removal of the N-terminal inhibitory domains. Cre-mediated recombination removed the STOP/selection cassette. (J:224320)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vav2 Mutation: 48 strains or lines available

References

• Original: J:224320 Fabbiano S, et al., Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells. Mol Cell Biol. 2014 Dec;34(24):4404-19
• All: 2 reference(s)