Wipf1^tm2.1Geha
Targeted Allele Detail

Summary

• Symbol: Wipf1^tm2.1Geha
• Name: WAS/WASL interacting protein family, member 1; targeted mutation 2.1, Raif S Geha
• MGI ID: MGI:5750987
• Synonyms: WIPdeltaABD
• Gene: Wipf1 Location: Chr2:73259954-73359831 bp, - strand Genetic Position: Chr2, 43.68 cM
• Alliance: Wipf1^tm2.1Geha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224328
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a modified exon 2 with a 36 nt deletion encoding amino acids 43 to 54 of the actin-binding domain. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted after the modified exon 2. (J:224328)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wipf1 Mutation: 29 strains or lines available

References

• Original: J:224328 Massaad MJ, et al., Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Mol Cell Biol. 2014 Dec 1;34(23):4343-54
• All: 3 reference(s)