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Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Sophia Y Tsai
MGI ID: MGI:5750673
Synonyms: CAG-S-COUP-TFII, COUP-TFIIOE
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194187
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa expresses 1 gene
 
Mutation detailsA conditional over-expression cassette was inserted into the locus. The cassette contains a CAG promoter, floxed STOP cassette, FLAG- and myc-tagged mouse cDNA and polyadenylation sequence.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  502 strains or lines available
References
Original:  J:194187 Qin J, et al., COUP-TFII inhibits TGF-beta-induced growth barrier to promote prostate tumorigenesis. Nature. 2013 Jan 10;493(7431):236-40
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory