Dio2^tm1Prla
Targeted Allele Detail

Summary

• Symbol: Dio2^tm1Prla
• Name: deiodinase, iodothyronine, type II; targeted mutation 1, P Reed Larsen
• MGI ID: MGI:5750651
• Synonyms: D2^fl
• Gene: Dio2 Location: Chr12:90691326-90705812 bp, - strand Genetic Position: Chr12, 44.05 cM
• Alliance: Dio2^tm1Prla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220761
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and neo cassette were inserted in intron 1 and a second loxP site was inserted in the 3' UTR of exon 2 via homologous recombination. (J:220761)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dio2 Mutation: 18 strains or lines available

References

• Original: J:220761 Luongo C, et al., The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism. Endocrinology. 2015 Feb;156(2):745-54
• All: 3 reference(s)