Npr1^tm1.2Kkan
Targeted Allele Detail

Summary

• Symbol: Npr1^tm1.2Kkan
• Name: natriuretic peptide receptor 1; targeted mutation 1.2, Kenji Kangawa
• MGI ID: MGI:5750457
• Synonyms: GC-A^-
• Gene: Npr1 Location: Chr3:90357898-90373173 bp, - strand Genetic Position: Chr3, 39.23 cM
• Alliance: Npr1^tm1.2Kkan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220676
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 1 and a loxP site was inserted downstream of exon 1 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exon 1. (J:220676)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npr1 Mutation: 60 strains or lines available

References

• Original: J:220676 Nojiri T, et al., Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells. [RETRACTED}. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4086-91
• All: 1 reference(s)