About   Help   FAQ
Loxl2tm1.1Acan
Targeted Allele Detail
Summary
Symbol: Loxl2tm1.1Acan
Name: lysyl oxidase-like 2; targeted mutation 1.1, Amparo Cano
MGI ID: MGI:5750226
Synonyms: L2fl
Gene: Loxl2  Location: Chr14:69846517-69933283 bp, + strand  Genetic Position: Chr14, 36.06 cM
Alliance: Loxl2tm1.1Acan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:220689
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:220689)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Loxl2 Mutation:  18 strains or lines available
References
Original:  J:220689 Martin A, et al., Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression. EMBO J. 2015 Apr 15;34(8):1090-109
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/21/2024
MGI 6.23
The Jackson Laboratory