Slc12a5^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Slc12a5^tm1.1Geno
• Name: solute carrier family 12, member 5; targeted mutation 1.1, Genoway
• MGI ID: MGI:5749483
• Synonyms: S940A
• Gene: Slc12a5 Location: Chr2:164802766-164841651 bp, + strand Genetic Position: Chr2, 85.28 cM, cytoband G2-G3
• Alliance: Slc12a5^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220314
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A loxP site was inserted upstream of exon 21, an exon 22 with an S940A mutation and an FRT flanked neo cassette and loxP site were inserted downstream of exon 24 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:220314)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a5 Mutation: 46 strains or lines available

References

• Original: J:220314 Silayeva L, et al., KCC2 activity is critical in limiting the onset and severity of status epilepticus. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3523-8
• All: 11 reference(s)