Ripk1^tm1.1Gsk
Targeted Allele Detail

Summary

• Symbol: Ripk1^tm1.1Gsk
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 1; targeted mutation 1.1, GlaxoSmithKline
• MGI ID: MGI:5749467
• Synonyms: Ripk1^K45A
• Gene: Ripk1 Location: Chr13:34186346-34221130 bp, + strand Genetic Position: Chr13, 14.01 cM
• Alliance: Ripk1^tm1.1Gsk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228785
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 3 was replaced with a modified one in which a point mutation results in the amino acid substitution of alanine for lysine at position 45 (K45A). Flp-mediated recombination removed the FRT flanked neomycin resistance cassette with a 3' loxP site inserted downstream of the modified exon 3. (J:228785)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk1 Mutation: 32 strains or lines available

References

• Original: J:228785 Berger SB, et al., Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice. J Immunol. 2014 Jun 15;192(12):5476-80
• All: 27 reference(s)