Ripk1^tm1.2Pvdb
Targeted Allele Detail

Summary

• Symbol: Ripk1^tm1.2Pvdb
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 1; targeted mutation 1.2, Peter Vandenabeele
• MGI ID: MGI:5749417
• Gene: Ripk1 Location: Chr13:34186346-34221130 bp, + strand Genetic Position: Chr13, 14.01 cM
• Alliance: Ripk1^tm1.2Pvdb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217308
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 3 floxed. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:217308)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk1 Mutation: 32 strains or lines available

References

• Original: J:217308 Takahashi N, et al., RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. Nature. 2014 Sep 4;513(7516):95-9
• All: 1 reference(s)