Dhrs7b^tm1.1Sem
Targeted Allele Detail

Summary

• Symbol: Dhrs7b^tm1.1Sem
• Name: dehydrogenase/reductase 7B; targeted mutation 1.1, Clay F Semenkovich
• MGI ID: MGI:5749209
• Synonyms: PexRAP
• Gene: Dhrs7b Location: Chr11:60721457-60749249 bp, + strand Genetic Position: Chr11, 37.87 cM
• Alliance: Dhrs7b^tm1.1Sem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219976
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT flanked construct containing splice acceptor site, beta-gal, neo and polyA sequences and loxP site were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 3 via homologous recombination. The targeting vector (design ID 39122) was obtained from the EUCOMM repository. Flp mediated recombination removed the beta-gal, neo construct. (J:219976)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dhrs7b Mutation: 104 strains or lines available

References

• Original: J:219976 Lodhi IJ, et al., Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. Cell Metab. 2015 Jan 6;21(1):51-64
• All: 3 reference(s)