Ripk3^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Ripk3^tm1.1Geno
• Name: receptor-interacting serine-threonine kinase 3; targeted mutation 1, Genoway
• MGI ID: MGI:5749174
• Synonyms: Rip3^K51A
• Gene: Ripk3 Location: Chr14:56022452-56026314 bp, - strand Genetic Position: Chr14, 28.19 cM, cytoband C1
• Alliance: Ripk3^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219498
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Single point mutation
• Mutation details: A floxed exon 2 with a p.K51A mutation replaced the endogenous exon 2 and an FRT site flanked neomycin resistance gene cassette was inserted into intron 3 via homologous recombination. Flp-mediated recombination removed the neo cassette. The mutation renders the encoded peptide kinase-dead. (J:219498)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk3 Mutation: 34 strains or lines available

References

• Original: J:219498 Mandal P, et al., RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95
• All: 15 reference(s)