Igh^tm2Cmu
Targeted Allele Detail

Summary

• Symbol: Igh^tm2Cmu
• Name: immunoglobulin heavy chain complex; targeted mutation 2, Cornelis Murre
• MGI ID: MGI:5749156
• Synonyms: DhJh-TetO
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214635
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The genomic region adjacent to the DhJh segments was replaced by a tandem array containing 240 copies of the tet-operator3 via homologous recombination. The targeting vector also includes a pgk-neo selection cassette. (J:214635)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 47 strains or lines available

References

• Original: J:214635 Lucas JS, et al., 3D trajectories adopted by coding and regulatory DNA elements: first-passage times for genomic interactions. Cell. 2014 Jul 17;158(2):339-52
• All: 1 reference(s)