Kras^tm1.1Cmco
Targeted Allele Detail

Summary

• Symbol: Kras^tm1.1Cmco
• Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1.1, Christopher M Counter
• MGI ID: MGI:5708830
• Synonyms: Kras^ex3op
• Gene: Kras Location: Chr6:145162425-145195965 bp, - strand Genetic Position: Chr6, 77.37 cM, cytoband G2
• Alliance: Kras^tm1.1Cmco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220039
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A codon optimized version of exon 3 with 33 synonymous mutations converting 27 rare codons into more common codons and a floxed neo cassette replaced the endogenous exon 3. Cre mediated recombination removed the neo cassette. (J:220039)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kras Mutation: 76 strains or lines available

References

• Original: J:220039 Pershing NL, et al., Rare codons capacitate Kras-driven de novo tumorigenesis. J Clin Invest. 2015 Jan;125(1):222-33
• All: 2 reference(s)