Cdkn2a^tm4.1Rdp
Targeted Allele Detail

Summary

• Symbol: Cdkn2a^tm4.1Rdp
• Name: cyclin dependent kinase inhibitor 2A; targeted mutation 4.1, Ronald DePinho
• MGI ID: MGI:5708828
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^tm4.1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220039
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were left flanked by single loxP sites after an frt-flanked neo cassette was excised from intron 3 via FLP-mediated recombination. Cre mediated recombination then deleted exons 2 and 3. (J:87196)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 59 strains or lines available

References

• Original: J:220039 Pershing NL, et al., Rare codons capacitate Kras-driven de novo tumorigenesis. J Clin Invest. 2015 Jan;125(1):222-33
• All: 3 reference(s)