Tg(Camk2a-Grin2c/itTA)10Rsp
Transgene Detail

Summary

• Symbol: Tg(Camk2a-Grin2c/itTA)10Rsp
• Name: transgene insertion 10, Rolf Sprengel
• MGI ID: MGI:5708649
• Synonyms: TgCN10, Tg^CN10-itTA
• Transgene: Tg(Camk2a-Grin2c/itTA)10Rsp Location: unknown
• Alliance: Tg(Camk2a-Grin2c/itTA)10Rsp page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Transactivator)
• Mutation: Insertion
• Mutation details: The transgene expresses an "improved" tetracycline transactivator (itTA) protein under control of a forebrain-specific promoter fragment, comprising 8.5 kb of 5' flanking sequence and 84 base pairs of the first, noncoding exon, of the mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a) gene, followed by a 1.0 kb DNA fragment containing the first three exons, comprising a neuron restrictive silencer element (NRSE), of the mouse glutamate receptor, ionotropic, NMDA2C (epsilon 3) (Grin2, also called Nr2c) gene. (J:37107, J:96556)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:96556 Krestel HE, et al., A genetic switch for epilepsy in adult mice. J Neurosci. 2004 Nov 17;24(46):10568-78
• All: 2 reference(s)