Abl1^tm1.1Jyjw
Targeted Allele Detail

Summary

• Symbol: Abl1^tm1.1Jyjw
• Name: Abl proto-oncogene 1, non-receptor tyrosine kinase; targeted mutation 1.1, Jean YJ Wang
• MGI ID: MGI:5708412
• Synonyms: Abl1^mu
• Gene: Abl1 Location: Chr2:31578388-31694239 bp, + strand Genetic Position: Chr2, 21.86 cM, cytoband B
• Alliance: Abl1^tm1.1Jyjw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221235
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 11 was replaced with one in which fifteen nucleotide substitutions in the three nuclear localization sequences mutating the sites. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted into intron 10. (J:139259, J:221235)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abl1 Mutation: 94 strains or lines available

References

• Original: J:221235 Sridevi P, et al., Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity. Cell Death Differ. 2013 Jul;20(7):953-62
• All: 3 reference(s)