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Lamb3tm1.1Hosc
Targeted Allele Detail
Nomenclature
Symbol: Lamb3tm1.1Hosc
Name: laminin, beta 3; targeted mutation 1.1, Holm Schneider
MGI ID: MGI:5708309
Synonyms: LAMB3 628G>A
Gene: Lamb3  Location: Chr1:192976661-193026186 bp, + strand  Genetic Position: Chr1, 97.71 cM, cytoband H2-H6
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:218616
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
 
Mutation detailsA 628G>A mutation was inserted in exon 7 and an FRT flanked neo cassette was introduced in intron 8 via homologous recombination. Flp mediated recombination removed the neo cassette. PCR analysis indicates the production of a shorter transcript with deletion of exon 7 resulting in a frameshift and premaure stop codon (p.V189NfsX8). (J:218616)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lamb3 Mutation:  39 strains or lines available
References
Original:  J:218616 Hammersen J, et al., A New Mouse Model of Junctional Epidermolysis Bullosa: The LAMB3 628G>A Knockin Mouse. J Invest Dermatol. 2015 Mar;135(3):921-4
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory