Pdzd8tm1b(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Pdzd8tm1b(EUCOMM)Wtsi |
Name: |
PDZ domain containing 8; targeted mutation 1b, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5708255 |
Gene: |
Pdzd8 Location: Chr19:59285610-59334212 bp, - strand Genetic Position: Chr19, 54.65 cM
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Alliance: |
Pdzd8tm1b(EUCOMM)Wtsi page
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IMPC: |
Pdzd8 gene page |
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Mutant Cell Line: |
EPD0242_4_D07 |
Germline Transmission: |
Earliest citation of germline transmission:
J:204739
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Pgk_P
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Mutation details: Cre-mediated excision of the parental Pdzd8tm1a(EUCOMM)Wtsi allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. This created a frameshift that changed the phenylalanine (F) and isoleucine (I) at positions 333 and 334 to an asparagine (N) and a termination codon () (p.F333Nfs1).
(J:204739, J:317428, J:333387)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023; |
All: |
5 reference(s) |
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